The 5-Star Seal applies to long-term application tests which provide the maximum possible protection in order to rule out as far as possible subsequent skin reactions among the target demographic: products which have been tested in this way can be claimed as “Clinically tested”. The aim of our Safety-in-Use studies is to investigate products for tolerability and, as appropriate, efficacy according to clinical dermatology criteria. This service applies to the Original Dermatest® premium sector. Studies with this distinction go beyond determining the potential for skin irritation in terms of their significance.